None
Conditions
Interventions
Standard Nutrition Group:Calorie supply: 25–30 kcal/kg/day
Protein supply: 1.2–1.5 g/kg/day (calculated based on ideal body weight).
Multimodal Intervention Group:Calorie supply: 25–30 kcal/kg/day
Probiotics: Daily supplementation with a probiotic preparation containing specific strains such as Bifidobacterium, Lactobacillus, and Saccharomyces boulardii
?-3 unsaturated fatty acids: Daily supplementation with an enteral nutrition emulsion containing ?-3 unsaturated fatty acids to provide EPA + DHA >=2.0 g/day
High protein: Increase protein supply to 2.0 g/kg/day, supplemented via whey protein powder or a high-protein enteral nutrition formula.
Sponsors
Hebei General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who are over 18 years old and have recovered; 2. Those whose condition has stabilized after ICU treatment and have been transferred out of the ICU within = 3 points); 4. Expected to require enteral nutrition support for >= 2 weeks; 5. The patient or their legal representative has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Have organic intestinal diseases that affect nutrient absorption, such as short bowel syndrome and inflammatory bowel disease; 2. Have a clear history of allergic reaction to the intervention components; 3. Patients who have been using immunosuppressants or glucocorticoids for a long time; 4. Pregnant or lactating women; 5. Patients with malignant tumors, HIV, organ transplantation, etc. who have immune suppression; 6. Patients with severe liver and kidney dysfunction (Child-Pugh C grade, or eGFR < 30 mL/min/1.73m^2); 7. Patients at the end of life; 8. Patients who are currently participating in other clinical trials that may interfere with the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle mass;Muscle strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma diamine oxidase;D-LA;Lipopolysaccharide-binding protein;Fecal short-chain fatty acids;Interleukin-6;Tumor necrosis factor-a;Interleukin-10;Lymphocyte subset count;Regulatory T cells;Monocyte human leukocyte antigen-DR;Serum albumin;Prealbumin;Amino acid;The incidence of new infections during treatment in the intensive care rehabilitation unit;Length of stay in the intensive care rehabilitation unit; | — |
Countries
China
Contacts
Public ContactLijing Jia
Hebei General Hospital
Outcome results
None listed