Pancreatic cancer or breast cancer with lack of blood supply
Conditions
Interventions
Experimental group:Ultrasound stimulated microbubbles combined with vasodilator
Sponsors
The Second Affiliated Hospital of the PLA Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patient is required to sign the informed consent form; 2. Patients diagnosed with pancreatic cancer and breast cancer through pathological histology or cytology and requiring chemotherapy; 3. Patients with measurable and evaluable tumor lesions as determined by oncological assessment (ultrasound, CT or MRI), and diagnosed with pancreatic cancer and breast cancer with poor blood supply (in this study, we define poor blood supply as the blood perfusion area in the largest tumor section on ultrasound contrast imaging being less than 40% of the total tumor area); 4. Age 18-75 years old, gender not limited; 5. Expected survival period of more than 3 months; 6. WBC >= 3.5×10^9/L, ANC >= 1.5×10^9/L, PLT >= 80×10^9/L, Hb >= 90/L; 7. Laboratory test results confirm good function of all organs, ECOG score 0-1; 8. No history of other malignant tumors; 9. Good compliance, no mental disorders.
Exclusion criteria
Exclusion criteria: 1. Does not meet the inclusion criteria; 2. Pregnant or breastfeeding; 3. Allergic or hypersensitive to chemotherapy drugs and vasodilators; 4. Intestinal obstruction or incomplete intestinal obstruction; 5. Acute active infectious diseases, autoimmune diseases or immunodeficiency diseases history; 6. Large ascites; 7. With brain or bone metastases; 8. Undergoing other anti-tumor drug treatment or radiotherapy; 9. Participating in other clinical trials with an end time less than 4 weeks; 10. Acute myocardial infarction and low filling pressure; 11. Left heart dysfunction and low filling pressure; 12. Severe hypotension (systolic blood pressure lower than 90 mmHg); 13. Hypertrophic obstructive cardiomyopathy; 14. Constrictive pericarditis; 15. Pericardial tamponade; 16. Glaucoma; 17. Aortic stenosis or mitral stenosis; 18. Patients with severe liver and kidney function impairment; 19. Hypothyroidism, malnutrition and patients with low body weight.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under curve difference; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peak intensity; | — |
Countries
China
Contacts
Public ContactXiaoxiao Dong
The Second Affiliated Hospital of Army Medical University
Outcome results
None listed