Persistent atrial fibrillation
Conditions
Interventions
Intervention group: PVI combined with PWI ablation group
Control group:PVI only ablation group
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male individuals aged 18 years or older and 80 years or younger; 2. Diagnosed with persistent atrial fibrillation (defined as: at least 7 consecutive days with two or more complete electrocardiograms showing atrial fibrillation and no sinus rhythm during this period, or dynamic electrocardiogram indicating continuous atrial fibrillation); 3. Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Long-term persistent atrial fibrillation lasting more than 1 year; 3. Left ventricular ejection fraction less than 40% or NYHA cardiac function classification III - IV; 4. Left atrial anterior-posterior diameter greater than 55mm on echocardiography; 5. Patients with a life expectancy of less than 1 year due to non-cardiovascular factors; 6. Patients with uncontrolled hyperthyroidism, severe liver dysfunction (AST/ALT >= 3 times the upper limit of normal), or renal insufficiency (eGFR < 30 mL/min/1.73m^2); 7. History of previous atrial fibrillation ablation; 8. Presence of atrial and left atrial appendage thrombus combined with left atrial myxoma, pulmonary vein stenosis, or previous history of pulmonary vein stent implantation; 9. History of previous heart transplantation, complex congenital heart disease, history of severe mitral stenosis, or having undergone any cardiac surgery, valve surgery, atrial septal defect closure surgery; 10. Hypertrophic cardiomyopathy; 11. Patients with definite paroxysmal supraventricular tachycardia (AV node reentrant tachycardia or atrioventricular reentrant tachycardia); 12. Patients with implanted permanent pacemaker, dual-chamber pacemaker, or any type of implantable cardiac defibrillator (with or without dual-chamber pacing function); 13. Patients with contrast agent allergy, contraindications to ablation surgery, anti-arrhythmic drugs or anticoagulant drugs; 14. Patients with acute coronary syndrome, history of cardiac surgery, angioplasty or cerebrovascular accident within 12 weeks before enrollment; 15. Other situations that the researchers consider unsuitable for participation in the study; 16. Participating in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 12-month freedom from atrial arrhythmia recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| 12-month freedom from AF recurrence;Freedom from atrial arrhythmia recurrence with allowance of class I/III AADs;AF burden; | — |
Countries
China
Contacts
Public ContactRui Zeng
West China Hospital of Sichuan University
Outcome results
None listed