Severe aortic stenosis (severe AS)
Conditions
Interventions
Low TAPSE group:None
Preserved TAPSE group:None
Sponsors
People's Hospital of Guidong County Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with severe aortic stenosis who meet the indications in the Chinese clinical guidelines for transcatheter aortic valve implantation (TAVI); 2. Unsuitable for, or at high risk with, surgical aortic valve replacement (SAVR); 3. Age >= 65 years with symptomatic severe aortic stenosis; 4. Completed the standard pre-TAVI evaluation and meet the interventional eligibility criteria.
Exclusion criteria
Exclusion criteria: 1. Severe calcification of the aortic annulus or ascending aorta that would interfere with valve implantation; 2. Concomitant severe tricuspid regurgitation or other valvular disease requiring concomitant surgical intervention; 3. Severe right heart failure (e.g., TAPSE < 10 mm with persistent low cardiac output); 4. Severe bleeding diathesis or coagulopathy; 5. Expected survival < 1 year or marked frailty syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality at 30 days post-TAVI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in right ventricular function (TAPSE improvement);RV-PA coupling status (TAPSE/PASP ratio);TAPSE (mm);PASP (mmHg); | — |
Countries
China
Contacts
Public ContactCen Kaiyuan
People's Hospital of Guidong County Guangxi Zhuang Autonomous Region
Outcome results
None listed