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Study of tDCS Combined with Pivotal Response Training on Social Ability in Children with Autism

A study on the intervention effect of transcranial direct current stimulation combined with pivotal response training on social cognition in children with autism spectrum disorder based on near-infrared spectroscopy evaluation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126681
Enrollment
Unknown
Registered
2026-06-13
Start date
2026-06-14
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Specttrum Disorder

Interventions

transcranial Direct Current Stimulation+Pivotal Response Treatment:Transcranial Direct Current Stimulation (tDCS): anode placed on left dorsolateral prefrontal cortex (F3), cathode placed on right sup
combined with Pivotal Response Treatment (PRT), 30 minutes per session, 5 sessions per week for 12 weeks.
Pivotal Response Treatment:Pivotal Response Treatment (PRT), 30 minutes per session, 5 sessions per week for 12 weeks.

Sponsors

Jiamusi UniversityShenzhen Longhua Maternal and Child Health Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
4 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1. Meet the DSM-5 diagnostic criteria and clinically diagnosed with autism spectrum disorder (ASD); 2. Aged 4 to 6 years old; 3. Language ability is equivalent to 2 years old or above (S-S assessment reaches stage 4-1 or above); 4. Signed written informed consent by the guardian.

Exclusion criteria

Exclusion criteria: 1. Presence of intracranial metal implants, pacemaker, nerve stimulator, or other conditions unsuitable for tDCS; 2. History of organic brain disease, severe traumatic brain injury, brain tumor, intracranial infection, or epilepsy; 3. Severe cardiac, hepatic, renal, or respiratory system diseases; 4. Comorbid severe mental disorders or obvious aggressive/self-injurious behaviors; 5. Severe visual or hearing impairment affecting assessment and intervention; 6. Received tDCS, rTMS or other neuromodulation therapy within the past 3 months.

Design outcomes

Primary

MeasureTime frame
Social Responsiveness Scale;Autism Treatment Evaluation Checklist;Activation Intensity of Prefrontal-Temporoparietal Brain Regions ;—

Secondary

MeasureTime frame
Score of Social Cognition Domain inSocial Responsiveness Scale;Score of Social Domain in Autism Treatment Evaluation Checklist;Functional Connectivity of Prefrontal-Temporoparietal Brain Regions.;—

Countries

China

Contacts

Public ContactSong Fuxiang

Longhua District Maternal and Child Health Hospital, Shenzhen

13846137325@163.com+86 138 4613 7325

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026