Retinopathy of Prematurity
Conditions
Interventions
ROP premature group:None
Non-ROP premature group:None
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Gestational age < 37 weeks or birth weight < 2500 g; 2. Patients with ROP or without ROP; 3. Complete case data.
Exclusion criteria
Exclusion criteria: 1. Patients with other types of congenital ocular vascular malformations; 2. Patients with severe congenital malformations; 3. Patients with chromosomal abnormalities or inherited metabolic disorders; 4. Patients with incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in EFN protein levels between ROP infants and preterm infants without ROP;Effect of EFN on retinal vascular endothelial function in ROP infants;Differences in exosomal proteins; | — |
Secondary
| Measure | Time frame |
|---|---|
| Key differentially expressed proteins;Effect on adhesion function of human retinal microvascular endothelial cells (hREMCs);Intercellular adhesion molecule-1 (ICAM-1);E-selectin;CD44;Wound healing assay;Hematological analysis;C-reactive protein (CRP);Erythrocyte sedimentation rate (ESR);Coagulation profile;Procalcitonin (PCT);Liver and renal function;Electrolytes;Blood gas analysis;Urinalysis;Fecal routine examination;Retcom III fundus imaging; | — |
Countries
China
Contacts
Public ContactWang Yang
Children's Hospital of Chongqing Medical University
Outcome results
None listed