Pain
Conditions
Interventions
Trial group (Oxycodine group):Induction: Oxycodine 0.04-0.1 mg/kg (maximum total dose 3 mg), half of induction dose given 10 minutes before incision, with intraoperative supplementation. Postoperative
Control group (Sufentanil group):Induction: Sufentanil 0.2-0.5 µg/kg, half of induction dose given 10 minutes before incision, with intraoperative supplementation. Postoperative analgesia: Patient-con
Sponsors
Jilin Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Scheduled for primary laparoscopic surgery; 2. ASA physical status class I–III; 3. Body mass index (BMI) 18–30 kg/m^2; 4. Aged >18 years; 5. Provided written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of opioid abuse (by DSM-5 criteria); 2. History of analgesic dependency; 3. Received corticosteroid or immunotherapy within 6 months prior to surgery; 4. Previous abdominal surgery; 5. History of radiotherapy or chemotherapy; 6. Contraindications to epidural anesthesia; 7. Patients with psychiatric/behavioral disorders at risk of nonadherence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mechanical pain thresholds were assessed via pinprick testing within 1 cm of the surgical incision site and at the nondominant forearm at baseline (preoperatively), during PACU (Post-Anesthesia Care U;Resting and dynamic pain intensities were evaluated at 24 and 48 hours post-surgery using the Numeric Rating Scale (NRS, 0-10). Dynamic pain was assessed during activity (e.g., coughing, expectoration;Total intravenous opioid consumption within the first 24 and 48 hours postoperatively.; | — |
Countries
China
Contacts
Public ContactPiao Guangxi
Jilin Provincial People's Hospital
Outcome results
None listed