Capsaicin-induced acute experimental pain in healthy subjects
Conditions
Interventions
Experimental group:The study includes four stimulation conditions: group-target stimulation, individualized single-target stimulation, individualized dual-target stimulation, and sham stimulation. In
Sponsors
School of Life Science and Technology, Xidian University
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Aged 18–40 years, right-handed, physically healthy, without obvious somatic diseases, and able to understand the study procedures and provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. Individuals with severe somatic diseases, neurological disorders, or psychiatric disorders; 2. Individuals with a history of central nervous system diseases, such as epilepsy, traumatic brain injury, or brain tumors; 3. Individuals with chronic or persistent pain symptoms; 4. Individuals who have taken medications within the past month that may affect nervous system function or pain perception; 5. Individuals with alcohol abuse or drug use behaviors; 6. Pregnant or breastfeeding women; 7. Individuals unsuitable for MRI examination, such as those with metallic implants, cardiac pacemakers, or claustrophobia; 8. Individuals with scalp lesions or allergies to electrode materials; 9. Individuals allergic to capsaicin or similar topical irritants, or with skin damage, inflammation, or infection at the experimental site; 10. Individuals with contraindications to magnetic resonance imaging; 11. Individuals with severe sleep disorders or circadian rhythm disturbances, which may affect the stability of EEG signals; 12. Individuals with dependence on psychoactive substances or caffeine, or with abnormal recent intake; 13. Individuals unable to remain at rest during the experiment or with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity (NRS score); | — |
Secondary
| Measure | Time frame |
|---|---|
| EEG signal;Adverse Events; | — |
Countries
China
Contacts
Public ContactLiu Jixin
School of Life Science and Technology, Xidian University
Outcome results
None listed