Inoperable hilar and distal bile duct cancer
Conditions
Interventions
Experimental group:steep pulse therapy
Sponsors
Beijing Ditan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patient age: 18 - 85 years old, gender not limited; 2. Patients diagnosed with cholangiocarcinoma through histological or cytological examination, and who have undergone surgical or multidisciplinary consultation but are not suitable or refuse to 1undergo radical surgery; 3. Patients whose tumors are indicated by CT, MRCP, EUS, etc. to have locally invaded major blood vessels or distant metastasis, and cannot be surgically removed; 4. Karmofsky physical function score above 60 points; 5. Have ERCP indications; 6. Have signed written informed consent; 7. Preoperative serum total bilirubin level > 34.2 µmol/L;
Exclusion criteria
Exclusion criteria: 1. Combined with other malignant tumors; 2. Severe liver and kidney dysfunction, severe cardiac and pulmonary dysfunction, high bleeding risk, and recent occurrence of cardiovascular and cerebrovascular accidents, etc., patients unsuitable for surgery; 3. Pregnant or lactating women or those planning to get pregnant during the trial; 4. Patients with severe biliary stenosis where the ERCP guide wire cannot pass through the stenosis; 5. Using other treatment methods that may affect the observation, such as radioactive particle or particle stent implantation, P53 injection, oral chemotherapy, interventional therapy, etc. 6. Participated in other studies within 1 month before inclusion in the study; 7. Pregnant or planning to get pregnant during the trial; 8. Alcohol and/or drug abusers or those judged by the doctor to have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Technical success rate;Clinical success rate;Incidence of device defects; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complication rate;Incidence of adverse events, incidence of serious adverse events; | — |
Countries
China
Contacts
Public ContactPing Li
Beijing Ditan Hospital, Capital Medical University
Outcome results
None listed