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A retrospective case-control study on postoperative adjuvant therapy for high-risk recurrence patients after radical hepatectomy for liver cancer

A retrospective case-control study on postoperative adjuvant therapy for high-risk recurrence patients after radical hepatectomy for liver cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126643
Enrollment
Unknown
Registered
2026-06-12
Start date
2026-06-15
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

surgery,targeted treatment:None
None Preventative Treatment:None

Sponsors

The First Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion Criteria: 1. Patients diagnosed with liver cancer for the first time at our hospital, with no prior anti-tumor treatment; 2. Underwent radical resection (including surgical resection, radiofrequency ablation, or radiofrequency ablation combined with resection), and pathological confirmation of HCC after surgery; 3. Complete preoperative and postoperative examination data; 4. Followed up at our hospital for more than 2 years; 5. Patients in the postoperative adjuvant targeted therapy group must have used the medication for more than six months without interrupting treatment for over 3 months; 6. No severe adverse reactions to targeted or interventional therapy that forced treatment discontinuation; 7. Patients in the postoperative adjuvant therapy group did not receive any other anti-tumor treatments (including radiofrequency, surgery, radiotherapy, other drugs) before recurrence or metastasis, aside from targeted and interventional therapy.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1. Patients with HCC who are not receiving first-time treatment; 2. Non-radical resection, tumor markers not turning negative within 2 months post-surgery, or postoperative exams indicating residual tumor; 3. Pathological diagnosis not consistent with HCC; 4. Postoperative adjuvant therapy includes treatments other than interventional or targeted drugs, or patients enrolled in other clinical studies; 5. Lost to follow-up post-surgery or missing hospital-recorded follow-up for more than six months; discontinued targeted drugs for over 3 months due to adverse reactions and postoperative adjuvant therapy was less than six months.

Design outcomes

Primary

MeasureTime frame
Recurrence-free survival;

Secondary

MeasureTime frame
Time of recurrence;

Countries

China

Contacts

Public ContactYao Bowen

The First Affiliated Hospital of Xi'an Jiaotong University

ybwsplendid@126.com+86 29 8532 3905

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026