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Efficacy of Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules Combined with Combined Oral Contraceptives in the Treatment of Polycystic Ovary Syndrome: A Prospective Randomized Controlled Trial

Efficacy of Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules Combined with Combined Oral Contraceptives in the Treatment of Polycystic Ovary Syndrome: A Prospective Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126642
Enrollment
Unknown
Registered
2026-06-12
Start date
2026-06-16
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome (PCOS)

Interventions

Combined treatment group (Group B):Take Peferon for 1 month, and take Ulixetin for 3 cycles simultaneously.
The conventional treatment group (Group A):took Uziyue (Norgestrel-Retinoic Acid II) for 3 cycles.

Sponsors

Drum Tower Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. The subjects were 18-40-year-old females; 2. The females diagnosed with PCOS according to the Rotterdam criteria; 3. They voluntarily signed the informed consent form and were willing to participate in this study.

Exclusion criteria

Exclusion criteria: 1. Those with other endocrine disorders; 2. Those who have taken hormones within the last 12 weeks; 3. Those who have taken drugs that may interfere with sugar and lipid metabolism within the last month (such as insulin, glibenclamide, indomethacin, phentolamine, furosemide, phenytoin, cortisone, etc.); 4. Those with diseases that affect sugar and lipid metabolism (such as abnormal thyroid function, asthma, hypertension, diarrhea, inflammatory bowel disease, intestinal stress syndrome, gastrointestinal surgery history, etc.); 5. Those who smoke or drink alcohol; 6. Those with uncontrollable mental disorders (including history of mental illness hospitalization); 7. Those currently taking any drugs that affect appetite or have known effects on appetite; 8. Those currently taking probiotic drugs or foods; 9. Those with a history of venous or arterial thrombosis diseases, such as deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke (cerebral apoplexy); 10. Those with severe liver or kidney function abnormalities; 11. Breast cancer patients; 12. Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
Blood lipid levels;Blood sugar indicators;BMI (Body Mass Index);Waist-to-hip ratio;Intestinal microbiota parameters;

Countries

China

Contacts

Public ContactTian Wang

Drum Tower Hospital

1070156564@qq.com+86 25 8310 6666

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026