PrimaryOpen-AngleGlaucoma
Conditions
Interventions
Primary Open-Angle Glaucoma (POAG) group:None
Sponsors
The First Hospital of Hunan University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the POAG group: 1. Meets the diagnostic criteria for primary open-angle glaucoma in China: pathological high intraocular pressure [intraocular pressure measured >= 21 mmHg (measured by Goldman tonometer) for at least two times], characteristic damage of glaucoma in the fundus (retinal nerve fiber layer defect or changes in optic disc morphology) and/or glaucomatous damage in the visual field, open anterior chamber angle, and no other factors causing elevated intraocular pressure; 2. Can be clearly classified into the early visual field defect, intermediate visual field defect, and late visual field defect groups according to the international visual field staging method; 3. No obvious opacity of the refractive medium was found during systemic ophthalmic examination, and there were no other ocular diseases except glaucoma; 4. No severe systemic diseases and no history of drug allergy; 5. Age >= 18 years and = 0.8; 5. Age >= 18 years and <= 70 years; 6. No history of glaucoma in the family.
Exclusion criteria
Exclusion criteria: Exclusion criteria for the POAG group: 1. Normal tension glaucoma or ocular hypertension; 2. Lesions or opacity in the refractive media; 3. Other ocular diseases except primary open-angle glaucoma, such as trauma, retinal diseases, macular diseases, etc.; 4. Severe systemic diseases that cannot tolerate the examination; 5. A clear history of drug allergy; 6. Inability to cooperate with ophthalmic special examinations, such as visual field examination or multifocal ERG examination; 7. Age 70 years; 8. Severe mental or language disorders that prevent completion of the study as per the experimental protocol; 9. Severe diseases of the heart, brain, kidneys, liver, or hematopoietic system; 10. Pregnant or lactating patients; 11. Other organic eye diseases, such as macular holes, retinal detachment, or fundus hemorrhage; 12. Currently participating in other ophthalmic research experiments. Exclusion criteria for the control group: 1. Two or more measurements of intraocular pressure exceeding the normal range (10-21 mmHg); 2. Presence of visual field defects, visual field constriction, or irregular changes in the visual field; fundus examination reveals retinal diseases (such as retinal detachment, retinal vascular diseases, etc.), optic nerve diseases (such as optic atrophy, optic neuritis, etc.), macular diseases (such as macular degeneration, macular edema, etc.) or other fundus abnormalities; 3. Refractive error exceeding the range of 0 to -6.00D, astigmatism exceeding ±3.00D, including high myopia, high hyperopia, or high astigmatism, etc.; 4. Best corrected visual acuity 70 years; 6. Family history of glaucoma; 7. Long-term use of drugs that may affect the eyes, such as long-term use of glucocorticoid eye drops, which may cause elevated intraocular pressure, lens opacity, and other adverse ocular reactions; long-term use of certain drugs may affect vision or ocular metabolism, interfering with the research results; 8. Infectious diseases; 9. Severe mental or language disorders that prevent completion of the study as per the experimental protocol; 10. Severe diseases of the heart, brain, kidneys, liver, or hematopoietic system; 11. Pregnant or lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proteomics;metabonomics; | — |
Countries
China
Contacts
Public ContactPeng Qinghua
The First Hospital of Hunan University of Chinese Medicine
Outcome results
None listed