Sarcopenic obesity (SO)
Conditions
Interventions
experimental group:Replace conventional food protein with 48g of hydrolyzed whey protein
control group:Calorie-restricted high-protein diet combined with lifestyle intervention
Sponsors
Jiangjin Central Hospital of Chongqing
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80, male or female; 2. BMI >= 28 kg/m^2; 3. The appendicular skeletal muscle index (ASMI) is less than 7 kg/m^2 for males and less than 5.7 kg/m^2 for females, combined with a grip strength of less than 28 kg for males and less than 18 kg for females, or a walking speed of less than 1.0 m/s; 4. Provide informed consent, sign the informed consent form, and cooperate with the research.
Exclusion criteria
Exclusion criteria: 1. Taking medications or supplements that have known effects on body fat and muscle mass in the past 2 weeks (such as insulin, liraglutide, semaglutide, tildepeptide (GIP/GLP-1 receptor dual agonist), Mazdutide, statins, beta blockers, etc.); 2. Have undergone weight loss surgery in the past 3 months or intend to undergo weight loss surgery in the next 1 month; 3. Patients with severe stress state, refractory vomiting, severe diarrhea, or severe malabsorption syndrome; 4. Patients with severe abnormalities in heart, brain, liver, and kidney functions; 5. Accompanied by severe secondary hyperparathyroidism, uremia, cardiac insufficiency, abnormal blood coagulation, autoimmune deficiency, infection, hypercatabolic state, cachexia, and other metabolic or immune-related diseases; 6. Patients with severe gastrointestinal dysfunction or impaired liver and kidney function who cannot tolerate oral nutritional supplementation; 7. Patients with a large amount of exudative pleural/peritoneal effusion, or significant urinary protein; 8. Individuals who are allergic to any component of this product, as well as any factors deemed unsuitable for the study by the researchers; 9. Patients with mental or consciousness disorders who are unable to communicate; 10. Poor compliance, unable to cooperate with the researcher; 11. Patients with other conditions that researchers deem unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| grip strength;Body Fat Index;Skeletal muscle index of limbs;6-meter walking speed; | — |
Secondary
| Measure | Time frame |
|---|---|
| Kidney Function Test (Two Items);fasting blood glucose;Body fat mass;fasting insulin;uric acid;fasting C-peptide;abdominal circumference;Lipid Panel;skeletal muscle mass;weight;Gastrointestinal adverse reactions;BMI;Visceral fat area;Liver Function Panel (LFT-4); | — |
Countries
China
Contacts
Public ContactPeiYi Tang
Jiangjin Central Hospital of Chongqing
Outcome results
None listed