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Analysis of the Incidence and Associated Factors of Bone Resorption After Lesion Debridement Combined With Impaction Bone Grafting for Osteonecrosis of the Femoral Head

Analysis of the Incidence and Associated Factors of Bone Resorption After Lesion Debridement Combined With Impaction Bone Grafting for Osteonecrosis of the Femoral Head

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126632
Enrollment
Unknown
Registered
2026-06-12
Start date
2025-11-01
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ONFH

Interventions

Bone Resorption Group:None
Non-resorption Group:None

Sponsors

The Third Affiliated Hospital of Guangzhou University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1.Diagnosis of osteonecrosis of the femoral head (ONFH) based on MRI and X-ray or CT, confirmed according to the ARCO staging system (2019 revision) or Ficat classification, with ARCO stage II–III at the time of surgery. 2.Patients who underwent lesion debridement and impaction bone grafting for ONFH at our institution, with or without supplementary internal fixation. 3.Age between 18 and 65 years. 4.ONFH etiology classified as alcohol-induced, corticosteroid-induced, idiopathic, or post-traumatic, and previously managed with conservative treatment. 5.Patients who completed preoperative baseline imaging and underwent immediate postoperative CT, with =6 months of follow-up and at least two postoperative CT examinations. 6.Availability of complete perioperative and demographic data.

Exclusion criteria

Exclusion criteria: 1.Presence of advanced femoral head collapse, hip osteoarthritis, or acetabular pathology at baseline. 2.Patients who underwent core decompression, vascularized fibular grafting, tantalum rod implantation, or primary arthroplasty, instead of impaction bone grafting. 3.History of developmental dysplasia of the hip (DDH), slipped capital femoral epiphysis, Legg–Calvé–Perthes disease, or prior pelvic/femoral osteotomy. 4.Coexisting malignancy, significant metabolic bone disorders (e.g., hyperparathyroidism, Paget’s disease, osteogenesis imperfecta), or severe osteoporosis (T-score = -2.5). 5.Incomplete clinical data or poor-quality CT scans that preclude reliable Hounsfield Unit (HU) measurement.

Design outcomes

Primary

MeasureTime frame
Progression of femoral head collapse = 2 mm (Yes/No);Conversion to total hip arthroplasty (Yes/No);Presence of osteoarthritis (Yes/No);—

Countries

China

Contacts

Public ContactYu Zhao

The Third Affiliated Hospital of Guangzhou University of Chinese Medicine

19139788005@163.com+86 20 2229 2715

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026