Perioperative pain
Conditions
Interventions
Oliceridine group:Oliceridine is utilized for analgesic induction, intraoperative analgesic transition, and postoperative analgesia.
Sufentanil group:Sufentanil is utilized for analgesic induction, intraoperative analgesic transition, and postoperative analgesia.
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged =65 years, regardless of gender. 2.American Society of Anesthesiologists (ASA) physical status classification II-III. 3.Scheduled for elective radical gastrectomy under general anesthesia. 4.Provision of written informed consent by the patient or their legal guardian.
Exclusion criteria
Exclusion criteria: 1.Preoperative severe cognitive impairment (e.g., MMSE score <9), rendering the patient unable to cooperate with pain scoring and questionnaire completion. 2.Severe hepatic or renal dysfunction (Child-Pugh class C or eGFR <30 mL/min/1.73m²); severe cardiac dysfunction. 3.Severe preoperative gastrointestinal motility disorders (e.g., intestinal obstruction, chronic constipation, inflammatory bowel disease); coagulopathy; respiratory insufficiency (preoperative SpO2 <90% or requiring long-term oxygen therapy); poorly controlled diabetes mellitus; or preexisting psychiatric disorders. 4.Known allergy or hypersensitivity to oxycodone, sufentanil, or their pharmaceutical excipients, constituting a contraindication. 5.Emergency surgery; history of alcoholism or substance abuse; anticipated inability to wean from mechanical ventilation postoperatively. 6.Anticipated intraoperative blood loss exceeding 1000 mL; or occurrence of major intraoperative complications. 7.Concurrent participation in another clinical trial that could potentially interfere with the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recovery time after surgery;Pain Scores;Severity of Postoperative Nausea and Vomiting; | — |
Countries
China
Contacts
Public ContactSun wenjie
The first affiliated hostipal of nanchang university
Outcome results
None listed