Glaucoma
Conditions
Interventions
Glaucoma suspect:No intervention
normal-tension glaucoma (NTG):No intervention
primary open-angle glaucoma (POAG):No intervention
primary angle-closure glaucoma (PACG):No intervention
participants without clinical evidence of glaucoma:No intervention
normal controls without myopia or glaucoma:No intervention
Sponsors
Department of Ophthalmology and Visual Sciences (DOVS), Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are willing to participate in the study and able to give informed consent; 2. Belong to one of the following diagnostic categories: glaucoma suspect, normal-tension glaucoma (NTG), primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), myopia without clinical evidence of glaucoma, or normal control without myopia or glaucoma (defined as no glaucomatous optic neuropathy, normal visual fields and no pathological myopic fundus changes). 3. One eye or both eyes of each patient could be recruited for the study; 4. Best-corrected visual acuity (BCVA) of 20/25 or better; 5. The participant is 18 years or older; 6. At least two reliable VF results
Exclusion criteria
Exclusion criteria: 1. Secondary cause of glaucoma (previous trauma, steroid use, uveitis); 2. Ocular or systemic disease that may cause VF loss or optic disc abnormalities other than glaucoma (e.g., such as diabetic retinopathy, age-related macular degeneration, retinal vascular occlusion, or non-glaucomatous optic neuropathy.) 3. Pathological myopia 4. History of glaucoma surgery or corneal refractive surgery (except uncomplicated cataract surgery, laser capsulotomy, retinal barrier laser, or selective laser trabeculoplasty) 5. Inability to perform reliable VF; 6. The participant has a history of systemic or neurological disease known to affect visual function or electrophysiological recordings, such as demyelinating disease, stroke, or uncontrolled diabetes. 7. The study eye has media opacity equivalent to or worse than LOCS III grade 3 or any condition that precludes good-quality OCT, OCTA or PERG recordings. 8. Inability to safely place a fiber electrode, like marked corneal or conjunctival epithelial disease or severe dry eye.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| P50 and N95 amplitudes and latencies and their hemifield ratios; | — |
Countries
China
Contacts
Public ContactCHAN Pui Man Poemen
Department of Ophthalmology and Visual Sciences, CUHK
Outcome results
None listed