Diabetes was associated with mild cognitive impairment
Conditions
Interventions
Cognitive training intervention group:On the basis of standardized diabetes treatment, participants received computerized multi-domain and adaptive cognitive training for 12 weeks, 30 minutes per day
Control group:Standardized diabetes treatment was provided
Semaglutide intervention group :Simeglutide was added to the diabetes treatment regimen, with subcutaneous injections once a week starting at 0.25mg and increasing the dose as needed after 4 weeks, up
Sponsors
Beijing Anzhen Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 50-75 years; 2. At least 6 years of education, with corrected hearing and vision within normal limits; 3. Previous confirmed diagnosis of type 2 diabetes; 4. HbA1c between 6.0% and 8.5%; 5. Subjective complaint of cognitive decline within the past year; 6. Performance in any cognitive domain assessed by the Basic Cognitive Aptitude Tests (BCAT) is more than 1 standard deviation below the mean of the normal population; 7. Willingness to undergo cognitive function testing and randomization for the study, and ability to comply with follow-up requirements.
Exclusion criteria
Exclusion criteria: 1. Alcohol abuse or current use of medications that affect cognitive function (antihistamines, antipsychotics); 2. Cognitive impairment caused by neurological disorders such as traumatic brain injury, brain tumors, severe cerebrovascular disease, or Parkinson's disease; 3. Psychiatric disorders affecting cognitive function, such as severe depression, mania, bipolar disorder, or schizophrenia; 4. History of stroke within the past 6 months; prior neurosurgery; 5. Previously confirmed diagnosis of dementia; 6. Inability to master the use of cognitive training equipment after two training sessions totaling 120 minutes; 7. Use of GLP-RA within the past 3 months; medullary thyroid carcinoma; severe gastrointestinal diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in MoCA scores in each group;Changes in any cognitive domain, such as processing speed and working memory,;Prolonged delay in pCASL measurement has been associated with changes in blood flow perfusion in known cognitively relevant regions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in MMSE;Diabetes pain scale score;WHO-5 happiness index;Emotion scale scores;Pittsburgh Sleep Scale scores;Daily living ability (scale) score;Prolonged delay pCASL measurement of perfusion changes in other brain regions; | — |
Countries
China
Contacts
Public ContactTao Hong
Beijing Anzhen Hospital, Capital Medical University
Outcome results
None listed