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The role of the digestive tract microbiota in the development of esophageal carcinogenesis and its mechanism

The role of the digestive tract microbiota in the development of esophageal carcinogenesis and its mechanism

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126604
Enrollment
Unknown
Registered
2026-06-12
Start date
2022-02-17
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal carcinoma

Interventions

Healthy Control group:None

Sponsors

Mianyang Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Selection criteria for the experimental group Patients who were admitted to the hospital for esophageal cancer from August 1, 2021 to August 1, 2023 and could undergo esophageal cancer resection. 2. The control group was healthy adults who matched the gender and age of the experimental group.

Exclusion criteria

Exclusion criteria: 1. Age < 18 years old. 2. Dysentery, schistosomiasis, intestinal tuberculosis, radiation enteritis, inflammatory bowel disease, ischemic enteritis, irritable bowel syndrome, intestinal tumors and other digestive diseases. 3. Those who are pregnant or breastfeeding. 4. Those with a history of serious infectious diseases, such as AIDS, syphilis, etc. 5. Severe heart, lung, kidney dysfunction and metabolic diseases.

Design outcomes

Primary

MeasureTime frame
Gut microbiota;

Secondary

MeasureTime frame
Measurement of esophageal cancer-related bacterial IgG/IgA in serum;Immunohistochemistry of esophageal cancer tissue and adjacent tissue;

Countries

China

Contacts

Public ContactXiaoan Li

Mianyang Central Hospital

435445611@qq.com+86 816 2239224

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026