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Research on Theta Burst Stimulation Reshaping White Matter Fiber Tracts in the Brain to Improve Upper Limb Function after Stroke

Clinical research on promoting the rehabilitation of stroke patients through non-invasive neuroregulation techniques

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126601
Enrollment
Unknown
Registered
2026-06-12
Start date
2025-03-31
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

Intermittent Theta pulse stimulation group:Undergo intermittent Theta pulse stimulation once a day for a period of thirty days
Continuous Theta pulse stimulation group:Undergo continuous Theta pulse stimulation once a day for a period of thirty days
Sham stimulation group:Undergo a 30-day sham stimulation once a day

Sponsors

The Second Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Meets the diagnostic criteria for stroke; 2. Passes the TMS safety screening test; 3. 18 years or older; 4. Passes the short version of the International Neuropsychiatric Interview; 5. Provides informed written consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1.Any contraindications to transcranial magnetic stimulation; 2.Those who refuse to participate in the experiment; 3.There is a history of previous neurological or mental system diseases; 4.There are severe consciousness disorders and cognitive dysfunction, and they are unable to follow the treatment. 5.Extreme spasm of one side of the upper limb (modified Ashworth score >3) or severe pain that hinders the movement of the upper limb; 6.Other obvious injuries to the upper limbs that were not affected by the stroke; 7.Obviously unable to speak or having difficulty understanding the instructions of the investigator; 8.Patients with severe organic heart diseases, such as myocardial infarction, heart failure, severe arrhythmia, pacemaker implantation, and those with untreated or drug-uncontrolled hypertension

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Assessment of motor function;The number of corticospinal tracts and anisotropy;

Secondary

MeasureTime frame
Transcranial magnetic stimulation motor threshold;

Countries

China

Contacts

Public ContactYin Yin

The Second Affiliated Hospital of Chongqing Medical University

300735@cqmu.edu.cn+86 138 8303 2886

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026