high-risk multiple myeloma
Conditions
Interventions
Observation Group:None
Sponsors
Beijing Chao-Yang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients with high-risk myeloma who have received CAR-T therapy; 2.Age >= 18 years; 3.Expected survival >= 12 months; 4.Voluntarily sign the informed consent form approved by the ethics committee;
Exclusion criteria
Exclusion criteria: 1.Patients with active hepatitis B (HBV), hepatitis C (HCV), and other acquired or congenital immunodeficiency diseases. 2.Presence of severe thrombotic events before treatment. 3.Patients with uncontrolled or severe cardiovascular diseases, including myocardial infarction within 6 months before enrollment, heart failure of NYHA class ? - ?, uncontrolled angina pectoris, clinically significant pericardial diseases or cardiac amyloidosis. 4.Patients with epilepsy, dementia and other mental disorders requiring drug treatment who cannot understand or comply with the research protocol. 5.According to the protocol or the judgment of the researcher, patients with severe physical or mental diseases that may interfere with their participation in this clinical study. 6.Drug abuse, medical, psychological or social conditions that may interfere with the subject's participation in the study or the evaluation of the study results. 7.Patients who are currently receiving treatment with other investigational drugs. 8.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression Free Survival(PFS);Overall Response Rate(ORR); | — |
Secondary
| Measure | Time frame |
|---|---|
| MRD negativity rate(MRD);Overall survival(OS);Complete Response Rate(CRR);Progression-free Survival(PFS); | — |
Countries
China
Contacts
Public ContactAijun Liu
Beijing Chao-Yang Hospital, Capital Medical University
Outcome results
None listed