Benign Prostatic Hyperplasia
Conditions
Interventions
Oxycodone group:Oxycodone was used as the opioid for both anesthesia induction and maintenance
Sufentanil group:Sufentanil was used as the opioid for both anesthesia induction and maintenance
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Male
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Male patients scheduled for elective transurethral resection of the prostate (TURP) or holmium laser enucleation of the prostate (HoLEP) under general anesthesia; 2.Aged 50–75 years; 3.Body mass index (BMI) between 18 and 28 kg/m2; 4.American Society of Anesthesiologists (ASA) physical status classification I or II; 5.Postoperative indwelling of a F20 three-way urinary catheter;
Exclusion criteria
Exclusion criteria: 1.Allergy to oxycodone or sufentanil; 2.Use of anticholinergics, antihistamines, or sedatives within 24 hours before surgery; 3.Severe cardiovascular or respiratory disease, or hepatic or renal dysfunction; 4.History of chronic pain or long-term opioid use; 5.Concomitant neurological diseases affecting bladder function or sensation (e.g., multiple sclerosis, spinal cord injury); 6.Pre-existing overactive bladder, neurogenic bladder, or acute/chronic urinary tract infection before surgery; 7.Previous penile or prostate surgery; 8.History of urinary catheterization or indwelling catheter within the past 3 months; 9.Expected surgery duration 2 hours, or anticipated conversion to open surgery; 10.Refusal to participate in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate-to-severe CRBD within 6 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Analgesic rescue treatment;Rescue treatment for CRBD;Other adverse events;Excessive sedation;Incidence of moderate-to-severe CRBD at each time point;Emergence agitation;Overall incidence of CRBD at each time point;Respiratory depression;Postoperative pain severity;Patient satisfaction score;Postoperative nausea and vomiting;CRBD Severity Score; | — |
Countries
China
Contacts
Public ContactWang Liangrong
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed