gastric cancer
Conditions
Interventions
case series:None
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Confirmation of disease: Patients with pathologically confirmed gastric cancer who meet the criteria for neoadjuvant therapy. 2. Aged >=60 years, male or female. 3. Basic literacy level. 4. No previous history of other malignant tumors. 5. No severe comorbidities: No severe cardiac, pulmonary, hepatic, or renal dysfunction. 6. Complete postoperative pathological staging available. 7. Complete medical records: Including preoperative evaluation, operation records, postoperative care, and follow-up information. 8. Postoperative follow-up and survival: Patients with at least 6 months of complete postoperative follow-up records.
Exclusion criteria
Exclusion criteria: 1. Previous diagnosis of dementia (e.g., definite Alzheimer’s disease or other progressive neurodegenerative diseases). 2. Severe psychiatric disorders. 3. Prior cranial radiotherapy / significant brain lesions. 4. Contraindications to brain MRI. 5. Severe hearing or visual impairment that would interfere with the completion of questionnaires and scales. 6. Use of substances active in the central nervous system (CNS) and known to affect cognition within 3 weeks prior to testing (e.g., anesthetics, antiemetics, or steroids).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional Assessment of Cancer Therapy - Cognitive function issues;Brain Magnetic Resonance Imaging;a/ß diversity and genus-level relative abundance of the gut microbiome.;fecal metabolites;Pro-inflammatory cytokines (TNF-a, IL-6, IL-1ß, IL-8, etc.); | — |
Countries
China
Contacts
Public ContactQijun Lyu
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed