Postoperative acute pain
Conditions
Interventions
Tegileridine group:10 minutes after the patient was extubated, a loading dose of tegretol was started to be pumped. 1 mg of tegretol was diluted to 10 ml, with a pumping rate of 60 ml/h. The pumping w
Oxycodone group:10 minutes after the patient was extubated, the loading dose of oxycodone (3 mg) was started to be pumped. The oxycodone was diluted to 10 ml, with a pumping rate of 60 ml/h. The pumpi
Placebo group:10 minutes after the patient was extubated, the loading dose placebo was started to be pumped. 10 ml of NS was prepared and pumped at a rate of 60 ml/h. The pumping was completed within
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18-65 years (inclusive of both ends); 2. ASA grades I-III; 3. Patients scheduled for elective laparoscopic total hysterectomy.
Exclusion criteria
Exclusion criteria: 1. Sleep apnea syndrome, with severe respiratory depression and pulse oxygen saturation 40 kg/m2); 4. Patients with a history of mental illness or cognitive impairment who cannot cooperate with the assessment; 5. Patients with moderate to severe liver or kidney dysfunction; 6. Patients with chronic pain history who have been taking analgesic drugs for a long time; 7. Patients who are allergic to opioids or any component of this product; 8. Patients with severe coagulation dysfunction; 9. Patients who refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The total difference in pain intensity at rest over the period from the start of administration of the loading dose to 24 hours (SPID24); | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting SPID and exercise SPID at 0.5 hours, 2 hours, 6 hours, 12 hours, 24 hours and 48 hours after the loading dose;The total pain relief scores (TOTPAR) at rest and during exercise at 0.5 hours, 2 hours, 6 hours, 12 hours, 24 hours and 48 hours after the loading dose;The first time to press the PCIA button;The time of first administration of analgesic rescue medication;The cumulative amount (calculated in terms of morphine equivalent) and the number of cases of rescue medication within 0 to 24 hours;QoR-15 on the 1st and 2nd days after surgery;Opioid-related adverse events (ORADEs);The first exhaust time and the time for getting out of bed and moving around; | — |
Countries
China
Contacts
Public ContactRong Ma
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed