mild cognitive impairment
Conditions
Interventions
Experimental group:quantified hierarchical progressive dual-task training
Control group:conventional hierarchical progressive dual-task training
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
45 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Consistent with Peterson’s diagnostic criteria for MCI. 2.Cognitive function: The Montreal Cognitive Assessment(MoCA) score ranges from 18 to 26 points, indicating mild cognitive impairment with attentional dysfunction as one of the prominent manifestations. 3.Activities of daily living (ADL): Barthel Index >=60, indicating basic independence in daily living; participants are capable of standing and walking for training independently or with minimal assistance. 4.Motor function and training tolerance: Subjects can complete standing and walking training with no or minimal assistance, possessing basic motor capacity to participate in combined cognitive-motor dual-task training. 5.Visual function and cooperation for eye-tracking: Visual acuity can be corrected to normal range with glasses or other corrective devices; no severe visual field defect, ocular movement disorder or color blindness, and subjects are able to cooperate to finish eye-tracking tests. 6.Comprehension and command execution ability: Participants have fundamental language comprehension and the capacity to follow instructions, able to understand simple assessment and training commands and complete relevant tasks under researchers’ guidance. 7.Informed consent: Participants voluntarily enroll in this study, fully understand the trial content and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Meet the diagnostic criteria for dementia or complicated with other confirmed neurodegenerative diseases. 2.History of or concomitant severe traumatic brain injury, Parkinson’s disease, epilepsy or other central nervous system disorders that may significantly impair cognitive or motor function. 3.Those with severe visual impairment, active ocular diseases or evident oculomotor disorders that interfere with the acquisition of valid eye-tracking data. 4.Those with marked vestibular dysfunction or severe balance impairment accompanied by high fall risk and ineligible for exercise training. 5.Those complicated with severe cardiopulmonary diseases, osteoarticular disorders or other conditions precluding tolerance to exercise training. 6.Those with severe depression, anxiety or other psychiatric disorders that may interfere with subject compliance and assessment outcomes. 7.Those who have received systematic cognitive training or combined cognitive-motor intervention within 3 months prior to study enrollment. 8.Subjects who develop severe adverse events during the trial or withdraw from training and assessments due to personal reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Digit Span Test score;comprehensive eye-tracking indicators;Trail Making Test score;MoCA; | — |
Countries
China
Contacts
Public ContactChuyan Wu
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed