Clear Cell Renal Cell Carcinoma
Conditions
Interventions
Renal Clear Cell Carcinoma (ccRCC) Clinical Cohort:None
Sponsors
Henan Provincial People's Hospita
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 18 years, any gender; 2. Underwent radical nephrectomy or partial nephrectomy at our hospital, with postoperative pathological histology confirming clear cell renal cell carcinoma (ccRCC); 3. Complete clinical and pathological data traceable (including patient age, gender, tumor size, Fuhrman grade, TNM stage, and survival follow-up data); 4. Sufficient formalin-fixed paraffin-embedded (FFPE) tissue retained in the pathology department, with good preservation conditions, meeting the quality requirements for immunohistochemistry and RNA extraction.
Exclusion criteria
Exclusion criteria: 1. Pathological diagnosis of non-clear cell carcinoma (such as papillary renal cell carcinoma, chromophobe carcinoma, etc.) or benign tumor; 2. Patients who have received neoadjuvant chemotherapy, radiotherapy, immunotherapy (such as PD-1/PD-L1 inhibitors), or targeted therapy before surgery (to avoid interference of treatments on metabolism and gene expression); 3. Patients with a history of malignant tumors in other systems; 4. Samples that have undergone severe autolysis or mold contamination, or FFPE samples evaluated to have been stored for too long resulting in severe RNA degradation, failing to meet transcriptome sequencing quality control requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression levels and modification levels of key proteins (SIRT5/SREBF1/SCD1);Patient prognosis; | — |
Countries
China
Contacts
Public ContactZhifeng Wang
Henan Provincial People's Hospita
Outcome results
None listed