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Model Development and Validation for the Timing of Renal Replacement Therapy Initiation in Patients with Sepsis

Model Development and Validation for the Timing of Renal Replacement Therapy Initiation in Patients with Sepsis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126515
Enrollment
Unknown
Registered
2026-06-10
Start date
2026-06-15
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Interventions

Group of Renal Replacement Therapy:None
Group of Non-Renal Replacement Therapy:None

Sponsors

Affiliated Hospital of Guangdong Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Included patients were aged over 18 years and met the Sepsis-3 diagnostic criteria. Sepsis was defined as suspected infection with an acute increase of = 2 points in the Sequential Organ Failure Assessment (SOFA) score. For patients with multiple episodes of sepsis during the same hospitalization, only the data from the first diagnostic episode was retained for analysis. 2. Patients with an ICU stay longer than 24 hours were included. For patients with multiple ICU admissions, only the data from the first admission was analyzed.

Exclusion criteria

Exclusion criteria: 1.Pregnant or lactating women; 2.Severely missing clinical data (missing rate of core predictive variables > 30%); 3.Patients with a prior diagnosis of chronic kidney disease (CKD) stage 4–5 or a history of long-term renal replacement therapy; 4.Patients who withdrew treatment, were transferred to hospice care within 24 hours of ICU admission, or had an expected survival time of less than 72 hours.

Design outcomes

Primary

MeasureTime frame
28-day mortality;

Secondary

MeasureTime frame
28-day RRT-free days;Precision;Accuracy;Recall;F1;area under the curve;

Countries

China

Contacts

Public ContactZhenhua Mai

Affiliated Hospital of Guangdong Medical University

maikson@126.com+86 759 2387093

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026