Severe Community-Acquired Pneumonia (SCAP)
Conditions
Interventions
Survival group vs. Non-survival group:None
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for community-acquired pneumonia (CAP), and are diagnosed as severe community-acquired pneumonia according to relevant guidelines. 2. Aged >= 18 years. 3. Serum cholinesterase test completed at admission, with complete clinical and laboratory data.
Exclusion criteria
Exclusion criteria: 1. Complicated with severe liver failure, liver cirrhosis, active liver disease or other liver diseases that can significantly affect cholinesterase synthesis. 2. Complicated with severe non-infectious severe stress states such as severe malnutrition, cachexia, severe burns or major trauma. 3. Have used organophosphorus pesticides, cholinesterase inhibitors or other drugs that can significantly affect serum cholinesterase activity within the past 3 months. 4. Hospital-acquired pneumonia, immunosuppression-related pneumonia, pulmonary tuberculosis, pulmonary fungal diseases and other atypical pulmonary infections. 5. Complicated with severe cardiac, renal, nervous system diseases or advanced malignant tumors, with an expected survival time < 28 days. 6. Pregnant or lactating women. 7. Loss to follow-up, or inability to cooperate with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality rate;Area under the ROC curve, sensitivity, specificity, positive predictive value, negative predictive value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate during hospitalization;Correlation coefficient between ChE score and outcome;Occurrence of severe complications (such as infection, bleeding, etc.); | — |
Countries
China
Contacts
Public ContactZhang Wenhui
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed