Parkinson's disease
Conditions
Interventions
Gold Standard:The final diagnosis should comply with the "Diagnostic Criteria for Parkinson's Disease in China" established in 2016. Determining the diagnosis of parkinsonian syndrome is a prerequisit
(2) levodopa-induced dyskinesia occurs
(3) resting tremor is observed in a single limb during clinical examination
(4) auxiliary examinations: 'olfactory reduction or loss,' or 'cranial ultrasound shows abnormally high echogenicity in the substantia nigra (>20 mm²),' or cardiac iodine-123-metaiodobenzylguanidine s
Index test:Multiparametric Imaging Diagnostic Model
Sponsors
Fuzhou University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients suspected of Parkinson's disease and Parkinsonian syndromes were collected based on clinical data, and those whose final diagnosis met the "Diagnostic Criteria for Parkinson's Disease in China" formulated by the Neurology Branch of the Chinese Medical Association in 2016 were included. 2. Control group: 30 healthy volunteers were included, with no history of severe mental disorders, no history of neurodegenerative diseases, trauma, or tumors. No contraindications for MRI examination, etc.
Exclusion criteria
Exclusion criteria: 1. Parkinsonism overlap syndrome includes Alzheimer's disease, vascular dementia, and psychiatric disorders; 2. Patients who have not completed clinical scales; 3. Poor compliance with MRI examination or contraindications to MRI, such as having a cardiac pacemaker, artificial cochlea, metallic foreign body in the eye, claustrophobia, pregnancy, etc.; 4. Poor MRI image quality, such as severe tremor, dyskinesia, or difficulty analyzing QSM images.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sensitivity;specificity;positive predictive value;negative predictive value; | — |
Countries
China
Contacts
Public ContactLin Shengmei
Fuzhou University Affiliated Provincial Hospital
Outcome results
None listed