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Exploration of the Optimal Dose Combination of Ciprofol and Oxycodone in Painless Oocyte Retrieval: A Randomized Controlled Trial Research Protocol

Exploration of the Optimal Dose Combination of Ciprofol and Oxycodone in Painless Oocyte Retrieval: A Randomized Controlled Trial Research Protocol

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600126501
Enrollment
Unknown
Registered
2026-06-10
Start date
2026-01-13
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

O1C1:Oxycodone 0.05 mg/kg
Ciprofol 0.3 mg/kg
O1C2:Oxycodone 0.05 mg/kg
Ciprofol 0.35 mg/kg
O1C3:Oxycodone 0.05 mg/kg
Ciprofol 0.4 mg/kg
O1C4:Oxycodone 0.05 mg/kg
Ciprofol 0.45 mg/kg
O1C5:Oxycodone 0.05 mg/kg
Ciprofol 0.5 mg/kg
O2C1:Oxycodone 0.075 mg/kg
O2C2:Oxycodone 0.075 mg/kg
O2C3:Oxycodone 0.075 mg/kg
O2C4:Oxycodone 0.075 mg/kg
O2C5:Oxycodone 0.075 mg/kg

Sponsors

The First Affiliated Hospital of Hebei North University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Female patients of childbearing age undergoing elective ultrasound-guided painless oocyte retrieval; 2. Aged 20–45 years; 3. With body mass index (BMI) of 18.5–28.0 kg/m^2; 4. And ASA physical status ? or ?.

Exclusion criteria

Exclusion criteria: 1. Severe systemic diseases, including but not limited to severe respiratory or cardiovascular disorders; 2. Clearly difficult airway; 3. Known allergy or contraindication to the study drugs oxycodone and ciprofol, or to any of their components; 4. History of asthma; 5. History of long-term analgesic use; 6. Allergy to any of the medications used; 7. Confirmed difficult airway; 8. High ovarian position requiring external abdominal pressure assistance; 9. Surgical duration = 30 minutes.

Design outcomes

Primary

MeasureTime frame
Heart rate;Systolic blood pressure;Diastolic blood pressure;Mean arterial pressure;Additional dose of Ciprofol;Wake-up time;Incidence of Adverse Reactions;Lower abdominal pain score at 1 hour postoperatively;

Countries

China

Contacts

Public ContactYan Xiaowen

The First Affiliated Hospital of Hebei North University

2296221775@qq.com+86 136 5323 1701

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026