Knee Osteoarthritis
Conditions
Interventions
Experimental Group:Ultrasound-guided adductor canal block with 5 mL mixture containing 0.665% liposomal bupivacaine (LB) plus 0.2% bupivacaine, with adaptive volume adjustment: the initial injection v
in the event of block failure, the volume is increased by 2 mL.
Sponsors
Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 60 and 80 years old; 2. Scheduled to undergo unilateral total knee arthroplasty (TKA) under general anesthesia; 3. Patients classified as American Society of Anesthesiologists (ASA) physical status I to III; 4. Body Mass Index (BMI) ranging from 18 to 25 kg/m².
Exclusion criteria
Exclusion criteria: 1. Patients who have a history of contralateral total knee arthroplasty within the past year or are scheduled for bilateral total knee arthroplasty; 2. Patients with infection, deformity at the adductor canal or femoral nerve puncture site of the affected limb on the ipsilateral side, or combined with other neurological disorders; 3. Patients with preoperative mental illnesses, cognitive dysfunction, language disorders or other conditions that result in impaired communication ability; 4. Patients with diseases requiring chronic analgesic treatment or opioid addiction; 5. Patients with significant preoperative abnormalities in liver and renal function, electrolytes and coagulation function, active or recurrent peptic ulcers, gastrointestinal bleeding or coronary heart disease; 6. Patients with allergy, hypersensitivity, intolerance or contraindications to medications used during the perioperative period; 7. Secondary surgery or emergency surgery cases; 8. Any other patients deemed ineligible for participation in this study by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting pain score (NRS) and effective compression times of patient-controlled analgesia (PCA) pump; | — |
Countries
China
Contacts
Public ContactWenping Liu
Hebei Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine
Outcome results
None listed