Depression, depressive state
Conditions
Interventions
Experimental group:Succinylcholine ? rocuronium bromide&sugeng sodium ? succinylcholine ? rocuronium bromide&sugeng sodium (succinylcholine 1mg/kg, rocuronium 0.6mg/kg, sugeng sodium 8mg/kg)
Control group:Rocuronium&sodium sugeng glucose ? succinylcholine ? rocuronium&sodium sugeng glucose ? succinylcholine (succinylcholine 1mg/kg, rocuronium 0.6mg/kg, sodium sugeng glucose 8mg/kg)
Sponsors
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Eligibility
Sex/Gender
All
Age
12 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 12–60 years; 2. Scheduled to undergo electroconvulsive therapy (ECT); 3. Patients and their family members are able to understand and sign the informed consent form; 4. Classified as physical status I–II according to the American Society of Anesthesiologists (ASA) classification.
Exclusion criteria
Exclusion criteria: 1. Known allergy to rocuronium, sugammadex, succinylcholine, or other related drugs; 2. Receiving medications that may cause serious interactions with the study drugs; 3. Pregnant or breastfeeding women; 4. Morbid obesity (>100 kg, BMI >35 kg/m^2); 5. Presence of definite airway management risks, including chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD) or asthma, upper respiratory tract infection, ventilation difficulty caused by abnormal cervicofacial anatomy, acute respiratory failure, or neuromuscular diseases (e.g., myasthenia gravis, amyotrophic lateral sclerosis); 6. Patients with autoimmune diseases; 7. Severe cognitive impairment or mental status preventing understanding and consent to participate in the study, or inability to sign the informed consent form; 8. Unwilling or unable to comply with follow-up requirements during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle relaxation recovery time (defined as the time from administration of the muscle relaxant to recovery of T1 to 90%).; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first spontaneous respiration recovery;Vital signs;Improvement in depressive symptoms;Anesthesia experience and adverse reactions;Seizure duration, seizure quality;Postoperative cognitive recovery time; | — |
Countries
China
Contacts
Public ContactYao Hui
Guangdong Second Provincial General Hospital (Guangdong Provincial Emergency Hospital)
Outcome results
None listed