Lower limb motor dysfunction after paraplegia
Conditions
Interventions
Experimental group:Precise Placement of Epidural Stimulator in the Spinal Canal
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years; 2. Paralysis following central nervous system injury (ASIA A, B, C), especially spinal cord injury above the T10 level; 3. Patients with injury duration of more than 9 months but within 5 years; 4. Mainly presenting with motor and sensory dysfunction in both lower limbs and having failed prior stepwise treatments (such as medication, physical therapy, interventional injections, etc.); 5. No significant atrophy of lower limb muscles, and electromyography shows no evidence of lower motor neuron damage from L2 to S1.
Exclusion criteria
Exclusion criteria: 1. High risk of infection: skin infection at the surgical site, systemic infection, or spinal infection/tumor; 2. Coagulation disorders: platelets <50×10^9/L, or use of anticoagulants not discontinued; 3. Abnormal neural structures: space-occupying lesions in the spinal canal (such as tumors) or anatomical variations caused by previous surgery; 4. Severe systemic diseases: uncontrolled diabetes, cardiovascular or cerebrovascular diseases (history of cerebral infarction, refractory hypertension), liver or kidney failure, active gastrointestinal bleeding, etc.; 5. Neurological comorbidities: epilepsy, Parkinson's disease, severe traumatic brain injury, cognitive impairment (unable to understand SCS operation equipment or cooperate with neurological function examination, etc.); 6. Immune system dysfunction and deficiencies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMT unarmed muscle strength assessment;Modified Ashworth classification;Holden walking ability rating;Gait analysis;Electromyography data; | — |
Countries
China
Contacts
Public ContactCao Xiaojian
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial People's Hospital)
Outcome results
None listed