Myopia
Conditions
Interventions
Experimental group:Topical administration of esculin and digitalis glycosides eye drops, one drop in each eye (OU), three times daily (TID), for 3 weeks.
Sponsors
The Zhongshan Ophthalmic Center,Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 28 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion age: 18 - 28 years old; 2. Inclusion of axial length and refractive status: patients with low myopia (AL = 26.5 mm); stable refractive status for >= 6 months; 3. Inclusion of myopia-related fundus changes: leopard-shaped fundus, optic disc tilt, peripapillary atrophy arc, etc., and confirmed by fundus SLO and OCT examination to have typical fundus changes; 4. Informed consent form has been signed.
Exclusion criteria
Exclusion criteria: 1.History of severe ocular surgery or ocular trauma. 2.Abnormal anterior segment structures (cornea, conjunctiva, iris) or abnormal intraocular pressure. 3.Significant abnormalities in corneal curvature or fundus examinations other than myopia-related changes. 4.Ocular diseases affecting posterior segment blood flow or structure (e.g., glaucoma, uveitis, chorioretinal atrophy). 5.Systemic diseases known to affect ocular hemodynamics (e.g., uncontrolled hypertension, diabetes, systemic autoimmune diseases, severe cardiovascular disease, rheumatic diseases). 6.Known allergy to esculin and digitalis glycosides or their components. 7.Recent use of other topical or systemic medications that may affect posterior segment blood flow. 8.Poor-quality SS-OCT/OCTA images, insufficient for choroidal and retinal blood flow analysis. 9.Wearing contact lenses on the day of examination, or intake of caffeine, tobacco, alcohol, or vigorous exercise within 24 hours prior to imaging. 10.Any other reason deemed inappropriate for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subfoveal Choroidal Thickness (SFCT);Macular Retinal Vascular Density (MVD);Choroidal Vascularity Index (CVI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Anterior segment parameters (corneal thickness/curvature, iris parameters, conjunctival indices);Choriocapillaris Flow Density;Retinal Nerve Fiber Layer (RNFL) thickness;Integrity of Macular Choroidal Structure (OCT-based); | — |
Countries
China
Contacts
Public ContactZhaotian Zhang
The Zhongshan Ophthalmic Center,Sun Yat-sen University
Outcome results
None listed