Heart failure Comorbid with Cognitive Impairment
Conditions
Interventions
Sponsors
Shijiazhuang Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 40-80 years; 2. Meets the diagnostic criteria for chronic heart failure, NYHA functional class II-IV; 3. Meets the neuropsychological scale (MMSE or MoCA) scoring criteria for cognitive impairment according to the "2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Disorders"; 4. Meets the diagnostic criteria for coronary heart disease: coronary angiography indicates stenosis >50%; 5. Subject has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients whose scale assessment results are affected by severe hearing, speech disorders, or other physical diseases; 2. Those with a history of severe depression, anxiety, schizophrenia, or other mental illnesses; 3. Patients with dementia, Parkinson's syndrome, epilepsy, or other diseases; 4. Patients with severe liver, lung, or kidney dysfunction, severe endocrine diseases, hematological diseases, or severe infectious diseases; 5. Those who have had a new acute cerebrovascular event within the past month; 6. Those with a history of alcohol or drug abuse or dependence, or a history of taking special medications, such as sedatives; 7. Pregnant or breastfeeding women and those allergic to this drug; 8. Those who have used antibiotics or probiotics within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination Score;Montreal Cognitive Assessment Score;Intestinal Microbiota;Intestinal Metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minnesota Living with Heart Failure Questionnaire; | — |
Countries
China
Contacts
Public ContactYingying Chang
Shijiazhuang Traditional Chinese Medicine Hospital
Outcome results
None listed