Fospropofol disodium
Conditions
Interventions
Propofol group:Anesthesia induction was performed using propofol for sedation.
Remimazolam combined with fospropofol group:Anesthesia induction was performed using remimazolam combined with fospropofol disodium.
Sponsors
People's Hospital of Jianyang City
Eligibility
Sex/Gender
All
Age
60 Years to 89 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60 to 89 years; 2. Scheduled to undergo elective laparoscopic surgery under general anesthesia with endotracheal intubation; 3. Body mass index (BMI) of 18 to 30 kg/m²; 4. American Society of Anesthesiologists (ASA) physical status classification ? to ?; 5. Voluntary participation in this trial and provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1. History of allergy to any medications used in the study; 2. History of neurological or psychiatric disorders, or long-term use of sedative agents; 3. History of severe cardiovascular diseases (e.g., coronary heart disease with chest tightness or angina pectoris, heart failure, or severe arrhythmia); 4. Uncontrolled hypertension (systolic blood pressure [SBP] = 160 mmHg or diastolic blood pressure [DBP] = 100 mmHg); 5. Abnormal liver function (alanine aminotransferase [ALT] and/or aspartate aminotransferase [AST] = 1.5 × upper limit of normal [ULN], total bilirubin [TBIL] = 1.5 × ULN); 6. Abnormal renal function (blood urea nitrogen [BUN] = 1.5 × ULN or creatinine [Cr] = 1.2 × ULN); 7. Suspected difficult airway (modified Mallampati classification Grade ?); 8. Any other conditions deemed unsuitable for study participation by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to reach 1 point on the Modified Observer's Assessment of Alertness/Sedation Scale (MOAA/S); | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in hemodynamics;Eyelash reflex disappearance time;The time when the Bispectral Index (BIS) depth of anesthesia drops to 60;Length of stay in the post-anesthesia care unit;Adverse effects;recover time; | — |
Countries
China
Contacts
Public ContactWenjie Mao
People's Hospital of Jianyang City
Outcome results
None listed