Sepsis
Conditions
Interventions
Sponsors
Yuebei People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Sepsis: (1) Age > 18 years; (2) Meet the Sepsis-3 diagnostic criteria for sepsis: confirmed or suspected infection with an increase in SOFA score (Sequential Organ Failure Assessment) of >= 2 points from baseline; (3) Develop sepsis within 72 hours of ICU admission; (4) Voluntarily sign the informed consent form (or signed by the legal representative). 2. Non-sepsis: (1) Age > 18 years; (2) No clear evidence of infection and not meeting the diagnostic criteria for sepsis; (3) Expected ICU treatment time >= 24 hours; (4) Voluntarily sign the informed consent form (or signed by the legal representative).
Exclusion criteria
Exclusion criteria: 1.Complicated with end-stage chronic organ failure (end-stage renal disease, decompensated liver cirrhosis (Child-Pugh Grade C), chronic heart failure NYHA Class IV), or malignant tumor; 2.Immunocompromised or suffering from autoimmune diseases, or long-term use of glucocorticoids/immunosuppressants within the past 3 months; 3.Pregnant and postpartum patients; 4.Patients with incomplete data collection; 5.Other conditions deemed unsuitable for participation in the study by the investigator (such as terminal state, refusal to cooperate with sample collection, or inability to cooperate with in-hospital and out-of-hospital follow-up).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Molecular Risk Stratification of Sepsis;Diagnostic performance: AUC, sensitivity, specificity, positive/negative predictive value;Core diagnostic markers of whole-genome mRNA expression profiles; | — |
Countries
China
Contacts
Public ContactZhao Pingsen
Yuebei People’s Hospital
Outcome results
None listed