Acute ischemic stroke
Conditions
Interventions
Probiotic intervention group (A group):Triple live tablets of Bifidobacterium longum, Lactobacillus bulgaricus, and Streptococcus thermophilus, 0.72×10^8 CFU daily, oral administration 30 minutes afte
Dietary management group (B group):Anti-inflammatory dietary management including whole grains, vegetables, fruits, meats, legumes, nuts, and dairy products, continuous for 8 weeks
Combined intervention group (C group):Probiotic modulation (same as A group) + dietary management (same as B group)
Control group (D group):Routine treatment and nursing care
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the stroke diagnostic criteria in the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke (2023), confirmed as acute ischemic stroke by head CT or MRI, with this admission for new-onset cerebral infarction; 2. Age between 18 and 80 years old, regardless of gender; 3. Stable condition, National Institutes of Health Stroke Scale (NIHSS) score of 4-16, moderate to severe neurological deficit, able to complete questionnaires and communicate; 4. No use of psychotropic drugs such as antipsychotics, antidepressants, or benzodiazepines in the past year; 5. No previous interventions related to the gut-brain axis: probiotic/prebiotic/synbiotic interventions, dietary and nutritional interventions, characteristic traditional Chinese medicine interventions (acupuncture, acupoint application, traditional Chinese medicine), psychological and behavioral interventions (mindfulness-based stress reduction, breathing training), fecal microbiota transplantation (FMT), etc.; 6. Obtain consent from the patient and their family members, be able to cooperate with relevant treatments and sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Complicated with other malignant tumors or dysfunction of vital organs; 2. Complicated with severe systemic infection; 3. Suffering from dementia, aphasia or disturbance of consciousness; 4. Those with mental illnesses (such as depression, schizophrenia, mania, etc.) and neurological diseases (such as Alzheimer's disease, Parkinson's disease, epilepsy, etc.); 5. Those with a history of severe intestinal-related diseases, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), etc., and who have used probiotics in the past 3 months; 6. Those with severe dysphagia and inability to eat orally.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post-stroke depression;The 17-item Hamilton Depression Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institutes of Health Stroke Scale Score;Improve the score of the Barthel Index Assessment Scale;Score of the Gastrointestinal Symptom Rating Scale;Modified Rankin Scale score; | — |
Countries
China
Contacts
Public ContactHu Tingting
The Second Affiliated Hospital of Harbin Medical University
Outcome results
None listed