Major Depressive Disorder
Conditions
Interventions
Intervention group:All participants received the two stimulation protocols in a random order (with a 7-day washout period): (1) 10 Hz TIS targeting the left DLPFC, (2) 0 Hz TIS (sham control).
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meets DSM-5 criteria for Major Depressive Disorder (MDD); first or recurrent episode. 2.Score of >14 on the 17-item Hamilton Depression Rating Scale (HAMD-17). 3.Age between 18 and 65 years. 4.No restriction on sex; 5.Han Chinese ethnicity; 6.Educational level of junior high school or above; 7.Normal vision or corrected-to-normal vision; 8.Right-handed, with adequate auditory, verbal, reading, and comprehension abilities to complete experimental tasks; 9.Either medication-naïve or on stable antidepressants for =4 weeks with no changes during the study; 10.Patient and their legal guardian (if applicable) have read, understood, and signed the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Diagnosed with other DSM-5 psychiatric disorders (e.g., organic mental disorder, substance use disorder, schizophrenia). 2.Current severe neurological condition (e.g., stroke, epilepsy, delirium); 3.Received physical therapies (e.g., ECT, TMS, tDCS) within the past 30 days; 4.Pregnant or breastfeeding women; 5.Contraindications to transcranial electrical stimulation (e.g., metallic implants, history/family history of seizures). 6.Any other factor deemed unsuitable for participation by the research team.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxyhemoglobin (HbO) concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Accuracy;Response Time; | — |
Countries
China
Contacts
Public ContactShen Li
Tianjin Anding Hospital
Outcome results
None listed