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Single-cell profiling reveals endothelial-driven multicellular remodeling in human skin photoaging

Single-cell profiling reveals endothelial-driven multicellular remodeling in human skin photoaging

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126396
Enrollment
Unknown
Registered
2026-06-08
Start date
2026-06-08
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin capillary dilation and pigmentation caused by photoaging due to sun exposure

Interventions

Photoaging group (Engaging in long-term outdoor activities without any sun protection for the head and face):None
Control group (Normal sunlight exposure):None

Sponsors

Chongqing University Three Gorges Hospital(Chongqing Three Gorges Central Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Willing to sign the informed consent form; 2. Aged 60 years or above, Gender not limited; 3. Engaged in long-term outdoor activities without any sun protection measures on the head and face, with clinical manifestations consistent with photoaging diagnosis; 4. The control group consists of skin tissues from absolutely sun-protected lumbosacral and abdominal regions of subjects in the same age group.

Exclusion criteria

Exclusion criteria: 1. Patients with skin tumors; 2. Pregnant or lactating women; 3. Those who have participated in other interventional clinical trials within the past one year.

Design outcomes

Primary

MeasureTime frame
Dermatopathology;

Countries

China

Contacts

Public ContactTiantian Liu

Chongqing University Three Gorges Hospital(Chongqing Three Gorges Central Hospital)

liutiantian579@sina.com+86 23 5810 3230

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026