Gout
Conditions
Interventions
Remission gout group:None
Acute gout group:None
Healthy control group:None
Sponsors
Ningbo First Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Acute Gout Group: (1) Male, aged 18–80 years; (2) Meet the 2015 ACR/EULAR gout classification criteria with a score =8 points; (3) In the acute flare phase of gout, defined as sudden redness, swelling, pain, fever, and tenderness in the affected joint or bursa; (4) Blood sample collected within 72 hours of symptom onset, and no use of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine, or glucocorticoids before blood collection. 2.Remission Gout Group: (1) Male, aged 18–80 years; (2) Previously definite diagnosis of gout; (3) At least 3 months since the last gout flare; (4) No acute inflammatory manifestations (redness, swelling, pain, fever, tenderness) in the affected joint or bursa in the past 3 months; (5) No active infection, fever, or other acute inflammation at the time of blood collection. 3.Healthy Control Group: Male, aged 18–80 years; healthy individuals from the same period’s health examination center, with no history of gout, autoimmune diseases, tumors, or chronic inflammatory diseases; normal liver and kidney function and normal inflammatory markers.
Exclusion criteria
Exclusion criteria: 1.Complicated with other autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus. 2.Complicated with acute infection, malignant tumor, severe cardiac, hepatic, or renal insufficiency, or immunodeficiency disease. 3.Use of immunosuppressants, or biologics within the past 3 months. 4.Incomplete medical records, unable to determine disease stage, or missing key clinical indicators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum IL-39 concentration; | — |
Secondary
| Measure | Time frame |
|---|---|
| C-reactive protein (CRP);White blood cell count (WBC);Liver function tests (ALT?AST?GGT?TBIL?DBIL?IBIL);Lipid profile (TG, TC, HDL-C, LDL-C);Absolute Neutrophil Count (ANC);Serum uric acid (UA);Renal function tests (Creatinine, Urea);Serum Amyloid A;Erythrocyte sedimentation rate (ESR); | — |
Countries
China
Contacts
Public ContactTingqi Zhao
Ningbo First Hospital
Outcome results
None listed