Obesity and MASLD
Conditions
Interventions
Normal+High-glucose meal:High-glucose meal
Normal+High-protein meal:High-protein meal
Normal+High-fat meal:High-fat meal
Normal+Mixed meal:Mixed meal
Overweight+High-glucose meal:High-glucose meal
Overweight+High-protein meal:High-protein meal
Overweight+High-fat meal:High-fat meal
Overweight+Mixed meal:Mixed meal
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 20 and 70 years, inclusive (20 = age = 70); 2. Good compliance, ability to complete electronic questionnaires using a smartphone, and willingness to undergo biological sample collection; 3. Complete clinical examination and laboratory test data, and meeting the predefined eligibility criteria; 4. Agreement to comply with the study requirements during the study period, accept the dietary intervention provided by the research team, and provide blood samples.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Individuals who have undergone surgery under general anesthesia within the past 3 months; 3. Individuals with a history of substance dependence according to DSM-5 criteria, including tobacco consumption of more than 20 cigarettes per day; 4. Individuals with known neurological, psychiatric, or systemic diseases that may affect cognitive function, including head trauma, subdural hematoma, current depression, and epilepsy; 5. Individuals with any other disease or major systemic condition that, in the investigator’s judgment, may affect study participation or outcome assessment, such as chronic kidney disease, heart disease, or chronic respiratory failure; 6. Individuals with strong pre-existing dietary preferences, special dietary requirements such as vegetarianism, or allergy to any food component used in the study; 7. Individuals who voluntarily withdraw from the study for subjective or objective reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Insulin + C-peptide (fasting and postprandial);Blood glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c;Hepatic function;Renal function;Blood omics analysis;Serum lipid profile;Serum uric acid;Blood routine;Blood pressure;Pulse rate;Height;Body weight;Chest circumference;Waist circumference;Hip circumference;Neck circumference;Body composition analysis;Ultrasonography;FibroScan; | — |
Countries
China
Contacts
Public ContactYao Zhenyu
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed