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Effects of Areca Nut on Postoperative Neurocognitive Disorders in Patients with Oral Cancer Undergoing Free Flap Reconstruction: A Prospective Observational Cohort Study

Effects of Areca Nut on Postoperative Neurocognitive Disorders in Patients with Oral Cancer Undergoing Free Flap Reconstruction: A Prospective Observational Cohort Study

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126386
Enrollment
Unknown
Registered
2026-06-08
Start date
2026-06-08
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Cancer

Interventions

group explored:NA
group non-explored:NA

Sponsors

Hospital of Stomatology, Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years 2. ASA classification I–III 3. No cognitive impairment prior to surgery (MoCA >= 26) 4. Signed informed consent form

Exclusion criteria

Exclusion criteria: 1. History of delirium or mental illness prior to surgery; 2. Significant hepatic or renal impairment prior to surgery (Child-Pugh Class C or eGFR < 30 ml/min); 3. Use of antipsychotic or sedative-hypnotic medication prior to surgery; 4. Inability to complete a cognitive assessment (e.g. illiteracy, severe visual or hearing impairment); 5. Emergency surgery or repeat surgery; 6. Cancellation of surgery or change in surgical approach; 7. Intraoperative cardiac arrest or other situations requiring resuscitation due to extreme instability of vital signs; 8. Postoperative requirement for mechanical ventilation

Design outcomes

Primary

MeasureTime frame
incidence of postoperative delirium (POD);

Secondary

MeasureTime frame
incidence of dNCR(delayed Neurocognitive Recovery,dNCR);Severity of delirum;incidence of postoperative complication;

Countries

China

Contacts

Public Contacthua xiaoxiao

Hospital of Stomatology, Sun Yat-sen University

huaxx3@mail.sysu.edu.cn+86 20 8387 1483

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026