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Efficacy and safety of modified minimally invasive subvastus approach versus medial parapatellar approach in primary total knee arthroplasty: a real-world cohort study using propensity score matching and stabilized inverse probability of treatment weighting

Efficacy and safety of modified minimally invasive subvastus approach versus medial parapatellar approach in primary total knee arthroplasty: a real-world cohort study using propensity score matching and stabilized inverse probability of treatment weighting

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126381
Enrollment
Unknown
Registered
2026-06-08
Start date
2026-06-14
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

Exposure group: Modified Minimally Invasive Subvastus Approach (MMSA) group:None
Control group: Medial Parapatellar Approach (MPA) group:None

Sponsors

Zhujiang Hospital, Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 40-80 years, regardless of gender, with skeletal maturity; 2. Meeting the 2019 ACR diagnostic criteria for knee osteoarthritis, with Kellgren-Lawrence grade IV; 3. Underwent unilateral primary TKA in our hospital from June 2020 to June 2022; 4. Complete clinical and imaging data; 5. Able to complete at least 2 years of postoperative follow-up; 6. Voluntarily participate and sign informed consent (or waiver of informed consent).

Exclusion criteria

Exclusion criteria: 1. Complicated with neuromuscular diseases (paralysis, rhabdomyolysis, myasthenia gravis, etc.); 2. Active infection, tuberculosis or tumor in the knee joint or whole body; 3. Severe osteoporosis (T-score = III; 5. Revision TKA, post-traumatic or rheumatoid arthritis-related TKA; 6. Missing key data or unable to complete 2-year follow-up; 7. Pregnant or lactating women; 8. Complicated with mental illness and unable to cooperate.

Design outcomes

Primary

MeasureTime frame
Oxford Knee Score;Western Ontario and McMaster Universities Osteoarthritis Index;Postoperative VAS score;—

Countries

China

Contacts

Public ContactLijun Lin

Zhujiang Hospital, Southern Medical University

1219875962@qq.com+86 62782020

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026