Cerebral Small Vessel Disease
Conditions
Interventions
Observation Group:None
Sponsors
Liaoning Chongwen Houde Hospital Co., Ltd.
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50-85 years. 2. Brain MRI findings meet the neuroimaging diagnostic criteria for cerebral small vessel disease (CSVD) according to the STRIVE criteria, with at least two of the following imaging markers: (1) lacune (diameter 3-15 mm); (2) moderate to severe white matter hyperintensities (Fazekas score >= 2); (3) cerebral microbleeds (>=1 in any lobar region on SWI); (4) moderate to severe enlarged perivascular spaces in the basal ganglia ("cribriform" appearance). 3. Conscious, able to understand the study content, and willing to sign the informed consent form by him/herself or by his/her legal guardian. 4. Able to cooperate and complete the approximately 20 minute clinical interview for apathy assessment.
Exclusion criteria
Exclusion criteria: 1. Dementia caused by large vessel disease (e.g., severe stenosis or occlusion of internal carotid artery or middle cerebral artery), intracranial space occupying lesions, traumatic brain injury, Parkinson's disease, Alzheimer's disease, or other definite etiologies. 2. History of clinically diagnosed mental disorders (e.g., major depressive disorder, schizophrenia, bipolar disorder), or currently taking antipsychotic medications. 3. Severe aphasia, deafness, or visual impairment that precludes completion of neuropsychological assessment. 4. Concomitant severe hepatic or renal dysfunction (e.g., end stage renal disease), malignant tumors, or other major systemic diseases that affect life expectancy. 5. Contraindications to MRI (e.g., cardiac pacemaker, metallic implants, etc.). 6. Unavailability of serum homocysteine (Hcy) test results within 3 months before enrollment, or incomplete brain MRI data (missing key sequences such as FLAIR or SWI).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma homocysteine (Hcy) concentration;Total cerebral small vessel disease (CSVD) neuroimaging burden score ;Apathy symptom severity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Age;Sex;Years of education;History of hypertension;History of diabetes;History of hyperlipidemia;Smoking history;Alcohol consumption history; | — |
Countries
China
Contacts
Public ContactLin Li
Liaoning Chongwen Houde Hospital Co., Ltd.
Outcome results
None listed