Postoperative pain
Conditions
Interventions
Experimental group:Sufentanil combined with midazolam in postoperative patient-controlled analgesia pump
Control group:Sufentanil in postoperative patient-controlled analgesia pump
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients undergoing thyroid surgery; 2. Aged 18-65 years; 3. Non-smokers; 4. American Society of Anesthesiologists (ASA) physical status classification Class I-II; 5. Patients who fully understood the trial procedures, participated voluntarily and signed informed consent forms.
Exclusion criteria
Exclusion criteria: 1. History of motion sickness or nausea and vomiting; 2. Long-term use of long-acting antiemetics, emetics, opioids or glucocorticoids; 3. Patients with known heart failure, liver failure or chronic kidney disease; 4. Patients complicated with severe systemic diseases, including severe heart disease, cerebral hemorrhage, severe chronic obstructive pulmonary disease (COPD), etc.; 5. Patients with other diseases that may cause nausea or vomiting, such as hepatitis or gastric ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of PONV (nausea/vomiting) within 48 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Generalized Anxiety Disorder-7 (GAD-7) scale was used to assess anxiety scores preoperatively, at 24 hours postoperatively and before discharge.;Pain scores at 6 h, 12 h, 24 h and 48 h postoperatively; | — |
Countries
China
Contacts
Public ContactLi Dongliang
Qilu Hospital of Shandong University
Outcome results
None listed