Neurodegenerative disease
Conditions
Interventions
cognitively normal individuals group:None
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for AD (SCD, MCI, or mild dementia: biomarkers supporting AD) or cognitively normal (CN) individuals; 2. Agree to provide fecal and plasma samples for testing, as well as imaging data, and be willing to undergo follow-up. 3. Participants voluntarily enroll in the study and provide written informed consent. For patients lacking full legal capacity, consent must be provided by their legal guardian.
Exclusion criteria
Exclusion criteria: 1. Individuals who have used broad-spectrum antibiotics within the past 2 months. 2. Individuals who have undergone bowel preparation within the past 2 months, or have inflammatory bowel disease, recent infection, or immunosuppressive therapy that may affect the study results; 3. Presence of serious diseases that may affect the study results (e.g., active malignancy, severe hepatic or renal insufficiency, severe cardiovascular disease, serious infectious diseases, etc.); 4. Participants whose blood or stool samples are of inadequate volume, poor quality, or cannot be analyzed due to technical issues. 5. Participants who cannot adhere to the study protocol or are likely to discontinue participation prematurely, including those with severe psychiatric disorders or language/communication impairments; 6. Participants who decline to provide informed consent, or individuals whose involvement in the study raises legal or ethical concerns. 7. Other conditions that the investigator determines make the participant unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| APOE genotype;Clinical Dementia Rating Scale Sum of Boxes, CDR-SB;Composition and diversity of gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination, MMSE;Brain MRI;Body Composition;Ptau181? Ptau217?GFAP?Nfl?Aß42/40 in serum;MoCA; | — |
Countries
China
Contacts
Public ContactLiu Zhou
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed