Cardiovascular-kidney-metabolic syndrome, sleep disorder, cognitive decline, mild cognitive impairment, dementia
Conditions
Interventions
MRI Subcohort (included within the main cohort):None
Overall observational cohort:None
Sponsors
Huai'an First People's Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Adults aged between 45 and 75 years. 2.who can communicate and cooperate with cognitive assessments and questionnaire surveys; 3.who can provide written informed consent and agreed to long-term follow-up; 4.agreed to the use of clinical, physical examination, and laboratory data for research purposes; 5.Those who have complete baseline core data (such as demographic information, cognitive assessment and major clinical indicators). The MRI subcohort is recruited from the main cohort. The inclusion criterion is: willingness to undergo magnetic resonance imaging (MRI) and polysomnography with electroencephalography (PSG-EEG) assessment.
Exclusion criteria
Exclusion criteria: 1.who have been clearly diagnosed with dementia, or who have obvious cognitive impairments and are unable to complete the cognitive assessment; 2.who have previously suffered from severe neurological disorders, which may significantly affect the assessment of cognitive functions, such as post-stroke sequelae, Parkinson's disease, brain tumors, epilepsy, and post-traumatic brain sequelae, etc. 3.Those with severe mental or psychological disorders or those who cannot cooperate in completing questionnaires and cognitive tests; 4.Those with severe visual, hearing or language communication impairments that prevent them from completing the cognitive assessment. 5.Those with severe systemic diseases or end-stage illnesses, who are expected to have difficulty completing long-term follow-up, such as advanced malignant tumors, severe heart failure, severe respiratory insufficiency, etc. 6.Missing key baseline data required for the primary analyses. The MRI subcohort is recruited from the main cohort. The exclusion criteria include: (1) inability to complete MRI, PSG, or cognitive assessments; (2) severe artifacts or inadequate quality in imaging or sleep monitoring data; (3) predominant central sleep apnea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| New-onset mild cognitive impairment (MCI) during follow-up;Longitudinal change in cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incident cardiovascular, cerebrovascular, and metabolic events;Change in domain-specific cognitive function;New-onset decline in cognitive function and new-onset dementia;Decline in daily functional status;Severity of OSA, hypoxia load, and other sleep phenotypes;Imaging indicators such as brain structural changes, cerebral small vessel lesions, and abnormal brain functional networks; | — |
Countries
China
Contacts
Public ContactXu Jing
Huai'an First People's Hospital
Outcome results
None listed