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A Study on Multimodal Neural Markers of Frequency-Following Response Characteristics in Hearing-Impaired Individuals Influenced by Musical Experience

A Study on Multimodal Neural Markers of Frequency-Following Response Characteristics in Hearing-Impaired Individuals Influenced by Musical Experience

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600126334
Enrollment
Unknown
Registered
2026-06-08
Start date
2026-06-15
Completion date
Unknown
Last updated
2026-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hearing impairment

Interventions

Hearing aid group: It includes the subgroup with musical experience and the subgroup without musical experience:None
Normal person group: It includes the subgroup with music experience and the subgroup without music experience:None
Cochlear implant group: It includes the subgroup with musical experience and the subgroup without musical experience:None

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Aged 18 to 70, right-handed, with normal cognitive function; 2.Speakers of Mandarin Chinese or dialects of tonal languages; 3.The hearing AIDS and cochlear implants in the hearing aid and cochlear implant groups were used for more than six months, and there were no device malfunctions or implantation complications; 4.The duration of hearing loss in the hearing aid and cochlear implant groups did not exceed 2 years and both were worn/implanted; 5.The average pure tone hearing threshold in the sound field is less than 40 dB;

Exclusion criteria

Exclusion criteria: 1.There are neurological disorders (such as stroke, epilepsy, Parkinson's disease, etc.) and mental disorders (such as depression, anxiety disorder, etc.) as well as left-handed people; 2.Other speakers of non-tonal languages; 3.Hearing aid devices are not used properly. They are worn for less than 4 hours a day, and are often worn intermittently or frequently adjusted by oneself; 4.The duration of hearing loss in the hearing aid and cochlear implant groups exceeded 2 years, and the hearing levels were asymmetrical after non-bilateral hearing aid; 5.Those with visual or speech impairments are unable to cooperate with the test, or have difficulty concentrating and cooperating during the test; 6.Organic diseases of the ear or otitis media, etc;

Design outcomes

Primary

MeasureTime frame
Signal-to-noise ratio loss in Quick-SIN,the signal-to-noise ratio threshold at a 50% accuracy rate in HINT;Micro-PROMS music perception ability score;The F0 fundamental frequency tracking intensity recorded by electroencephalogram (EEG);The spectral amplitudes and phase-locked values (PLV) of F0 (fundamental frequency) and higher harmonics (H2-H10) recorded by electroencephalogram (EEG);Source localization indicators and brain network connection indicators of magnetoencephalography;The cortical activation intensity and resting-state brain network indicators recorded by near-infrared brain functional imaging tests;

Secondary

MeasureTime frame
The sharpness and bandwidth of the 4kHz adaptive tuning tracking curve tuning curve graph;The signal-to-noise ratio threshold for 1000Hz sequence resolution under non-verbal information masking;threshold for expanding high-frequency testing;Pitch identification of 100Hz fundamental frequency harmonic compound tones;

Countries

China

Contacts

Public ContactHAOTIAN LIU

West China Hospital of Sichuan University

386319173@qq.com+86 28 8542 2881

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 21, 2026