Postoperative delirium
Conditions
Interventions
Dexmedetomidine combined with taVNS group:Dexmedetomidine anaesthesia was maintained during the operation, taVNS was started 5 minutes after anaesthesia induction and continued for 30 minutes, and taV
Dexmedetomidine group:Intraoperative maintenance of anaesthesia with dexmedetomidine
Sponsors
Jiangnan University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Perform elective non-cardiac surgery under general anesthesia, with operation time >=2 hours and =65 years old. 3. ASA grade I to III. 4. BMI 20.
Exclusion criteria
Exclusion criteria: 1. Patients with severe primary or secondary diseases; 2. Patients with a clear history of neurological or psychiatric disorders or who are using corresponding medications; 3. Patients with drug, alcohol, or other substance addiction; 4. Recent use of cholinergic drugs, anticholinergic drugs, or hormones; 5. Local rashes, infections, skin lesions, ulcers, or scars in the auricular region; 6. Patients allergic to dexmedetomidine; 7. Bradycardia (preoperative heart rate <60 beats per minute); 8. Patients with a history of implanted stimulators (such as pacemakers, implantable vagus nerve stimulators, deep brain stimulators, or spinal cord stimulators), cochlear implants, or metallic implants; 9. Patients who refuse to provide informed consent or refuse the analgesia pump.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate variability analysis;Postoperative pain score;Sleep quality score;Postoperative anxiety score;Postoperative depression score ;Inflammatory cytokines;Intraoperative vasoactive drug dosage;Opioid consumption;Number of patients requiring rescue analgesia;Any postoperative adverse events; | — |
Countries
China
Contacts
Public ContactXian Ding
Jiangnan University Affiliated Hospital
Outcome results
None listed