Postoperative delirium (POD)
Conditions
Interventions
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Group:Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
Sham Stimulation Group:Sham Stimulation
Sponsors
Wuxi No.2 People’s Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 65 years, meeting the definition of elderly patients; 2. Previously diagnosed with type 2 diabetes, with blood glucose basically under stable control; 3. Planned to undergo elective orthopedic surgery under general anesthesia (such as hip replacement, fracture internal fixation, etc., with an expected surgery duration of 1-5 hours); 4. Meets the PACU admission criteria postoperatively; 5. Patient and family are informed and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pre-existing cognitive impairment or cognitive dysfunction before surgery; 2.Preoperative sleep disorders; 3.Severe hearing impairment or external ear diseases (e.g., severe infection or malformation) that preclude auricular stimulation; 4.Implanted cardiac pacemaker or severe cardiac arrhythmias (e.g., high-grade atrioventricular block, sick sinus syndrome); 5.Requirement for prolonged sedation with endotracheal intubation during the perioperative period (making delirium assessment infeasible), or anticipated ICU stay >24 hours; 6.Any other conditions judged by the investigators to potentially interfere with the intervention or outcome assessment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Delirium (POD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory Stress Markers;Sleep Quality;Postoperative Pain and Adverse Events;Perioperative Glycemic Control;Anxiety and depression (HADS); | — |
Countries
China
Contacts
Public ContactDongxiao Huang
Wuxi No.2 People’s Hospital
Outcome results
None listed